Promethazine HCl and Codeine Phosphate Oral Solution is indicated for your non permanent relief of coughs and upper respiratory indications connected with allergy or maybe the prevalent cold in people eighteen yrs of age and more mature.
The concomitant utilization of Promethazine HCl and Codeine Phosphate Oral Solution with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may cause lessen codeine levels, bigger norcodeine amounts, and fewer metabolism by means of 2D6 with resultant decreased morphine degrees.
Bluish lips or skin chills clay-coloured stools chilly sweats confusion cough darkish urine minimize within the frequency of urination lessen in the urine volume diarrhea hard or troubled respiratory problems in passing urine (dribbling) dizziness dizziness, faintness, or lightheadedness when finding up from lying or sitting down place rapidly, pounding, or irregular heartbeat or pulse experience of heat fever headache higher fever hives or welts, itching, or rash greater perspiring irregular, rapid or gradual, or shallow breathing huge, hive-like swelling to the facial area, eyelids, lips, tongue, throat, arms, legs, ft, or sex organs loss of appetite loss of bladder Handle nausea noisy respiration not respiration agonizing urination pale or blue lips, fingernails, or skin rectal bleeding redness with the facial area, neck, arms, and occasionally, upper chest redness with the pores and skin observing, Listening to, or feeling items that are not there seizures critical muscle mass stiffness shakiness while in the legs, arms, or palms belly agony sweating tightness inside the upper body tiredness trembling or shaking on the fingers or toes disagreeable breath odor uncommon tiredness or weak point unusually pale pores and skin vomiting of blood yellow eyes or skin Get emergency assist promptly if any of the next signs and symptoms of overdose arise:
Utilize other supportive steps (which includes oxygen and vasopressors) within the administration of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced lifetime-guidance methods. Gastric emptying may be handy in getting rid of unabsorbed drug.
Impaired secretion from sweat glands next toxic doses of medicines with anticholinergic side effects may possibly predispose to hyperthermia.
Results within the Immune Program Opioids are already demonstrated read more to possess many different results on factors with the immune technique in in vitro and animal types. The medical significance of these conclusions is not known. In general, the consequences of opioids seem like modestly immunosuppressive.
Neuroleptic malignant syndrome (NMS) which can lead to Demise. Tell you Health care provider at once When you have any of the following symptoms of NMS: substantial fever
Codeine triggers miosis, even in overall darkness. Pinpoint pupils are an indication of opioid overdose but are certainly not pathognomonic (eg, pontine lesions of hemorrhagic or ischemic origins may perhaps deliver very similar findings). Marked mydriasis in lieu of miosis could be viewed as a result of hypoxia in overdose cases.
Tell your physician In the event your cough lasts, returns, or gets even worse right after 7 times or if it is accompanied by headache that does not disappear, fever, serious sore throat, or rash.
Tell your medical professional When you are Expecting or Believe you might be pregnant. All through pregnancy, this product is not really encouraged. It might hurt an unborn newborn. Speak with your medical professional with regards to the threats and advantages of this medication. See also Warning segment.
Area the mixture in a container for instance a sealed plastic bag and toss it away in the residence trash. It's also possible to comply with your state or local rules on how to safely toss away Promethazine Hydrochloride and Codeine Phosphate Oral Solution.
No proof of tumorigenicity was noticed in male and feminine mice at codeine dietary doses approximately four hundred mg/kg/working day (somewhere around reminiscent of 45 occasions the MRHD over a mg/m2 foundation).
These signs and symptoms could indicate that you will be an "ultra-fast metabolizer of codeine". Due to this fact, there may be excessive morphine in the human body and even more Unwanted side effects from morphine than regular. Kids might be Specifically sensitive to this impact. Don't give this medicine to:
Drug interactions, which include an increased incidence of extrapyramidal outcomes, have been described when some MAOI and phenothiazines are utilized concomitantly.